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This game also comes with an Free Spins bonus with multipliers that can be as high as 500x your stake.<br><br>Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from different geographical regions. This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also reduces bias in the results. However, too much heterogeneity can result in problems with the design of the trial.<br><br>Pragmatic Play is one of the biggest players on the live casino market, offers an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gambling experience, as well a full variety of betting options via virtual. The company also has created several interactive game shows to make gambling online enjoyable. 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However, they should not be used to substitute for explanatory trials.<br><br>The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which inform the policy and practice of. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a pragmatic trial, including the recruitment process, the design and delivery of the intervention, as well as monitoring.<br><br>There is a growing trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind that the majority were conducted in primary-care settings.